DeepTrack2 Logo. (Image by J. Pineda)deeplay: enhancing pytorch with customizable and reusable neural networks
Alex Lech, Mirja Granfors, Jiacheng Huang, Benjamin Midtvedt, Jesús Pineda, Harshith Bachimanchi, Carlo Manzo, Giovanni Volpe Date: 23 August 2026 Time: 2:15 PM – 2:30 PM PDT Place: Conv. Ctr. Room 2
Deeplay is a Python-based deep learning library that extends PyTorch, addressing limitations in modularity and reusability commonly encountered in neural network development. Built with a core philosophy of modularity and adaptability. Unlike traditional PyTorch modules, Deeplay allows the properties of submodules to be modified after creation. Layers, blocks, or activation functions can be replaced or reconfigured without rewriting the surrounding architecture, which reduces boilerplate code, improves reuse, and simplifies ablation studies.
Top: single gear; Bottom: the second gear from the right has an optical metamaterial that react to laserlight and makes the gear move. All gears are made in silica directly on a chip. Each gear is about 0.016 mm in diameter. (Image by G. Wang)Light-driven micromechanical gear systems
Antonio Ciarlo, Gan Wang, Marcel Rey, Mohanmmad Mahdi Shanei, Kunli Xiong, Giuseppe Pesce, Mikael Käll and Giovanni Volpe Date: 23 August 2026 Time: 9:30 AM – 9:45 AM PDT Place: Conv. Ctr. Room 11A
We present microscopic geared metamachines driven by optical metasurfaces and fabricated using standard lithography techniques. Metasurface elements convert incident plane-wave illumination into localized optical forces and torques, enabling direct on-chip actuation of micromechanical components without external drives. We demonstrate microscopic gear trains powered by a single optically activated gear and a pinion-and-rack micromachine capable of rotational-to-linear motion conversion and controlled mirror actuation. The platform is compatible with planar fabrication and scalable to parallel integration, providing a compact approach to chip-integrated optical actuation and micromechanical functionality.
Top: single gear; Bottom: the second gear from the right has an optical metamaterial that react to laserlight and makes the gear move. All gears are made in silica directly on a chip. Each gear is about 0.016 mm in diameter. (Image by G. Wang)Light-driven metamachines: From metarotors to integrated microscopic gear trains
(Keynote Presentation)
Giovanni Volpe Date: 23 August 2026 Time: 8:30 AM – 9:05 AM PDT Place: Conv. Ctr. Room 11A
Microscopic geared metamachines provide a powerful platform to control motion and mechanical work at the microscale. While the miniaturization of mechanical systems has been pursued for decades, integrating drives and gear trains at micrometer scales has remained a major challenge. Recent advances in optical metasurfaces and on-chip fabrication enable light-driven metarotors that transfer torque to passive gears under uniform illumination. These systems have been explored under various conditions by varying light polarization, intensity, and structural symmetry to achieve directional control, tunable rotation rates, and efficient torque transmission. Integrated designs such as rack-and-pinion configurations further demonstrate conversion of rotational motion into linear actuation within compact microsystems. More broadly, geared metamachines extend the landscape of light-powered micro- and nanomachines. In this presentation, I’ll give an overview of this field with a focus on metarotor design, torque transfer across microscopic gear trains, and integrated light-programmable micromechanical systems.
Illustration of three different experiments autonomously performed by the SmartTrap system: DNA pulling experiments (top), red blood cell stretching (bottom left), and particle-particle interaction measurements (bottom right). (Image by M. Selin.)Smart Machines and Optical Manipulation at the Microscale
Giovanni Volpe 5th Münster Symposium on Intelligent Matter (MüSIM) (Flyer) Date: 24 June 2026 Time: 15:00 Place: Center for Soft Nanoscience (SoN), Münster, Germany
Microscale systems offer a unique opportunity to engineer machines whose function emerges from the interplay of geometry, interactions, and fluctuations. In this talk, I will present our work on smart machines at the microscale, combining nanofabrication, programmable interactions, and advanced optical methods to design and control colloidal micromechanisms and metamaterials.
I will first introduce how nanotechnology enables the realization of colloidal metamachines and microscopic mechanisms, where shape and mechanical constraints are engineered to produce targeted motion and response in fluid environments. I will then show how smart microscopy and optical manipulation—including high-resolution imaging, automated tracking, and light-based control—allow us to probe these machines in real time and quantify their dynamics. This approach enables precision measurements of effective interaction landscapes, including critical Casimir forces and their relation to fluctuation-induced forces known from QED Casimir physics.
(Image created by G. Volpe with the assistance of DALL·E 2)What remain for physicists to do in the age of AI?
Giovanni Volpe
QT (Quantum Technology Division of MC2, Chalmers University of Technology) community building activity 2026 Date: 11 May 2026 Place: Stenungsbaden Yacht club
In recent years, the rapid growth of artificial intelligence, particularly deep learning, has transformed fields from natural sciences to technology. While deep learning is often viewed as a glorified form of curve fitting, its advancement to multi-layered, deep neural networks has resulted in unprecedented performance improvements, often surprising experts. As AI models grow larger and more complex, many wonder whether AI will eventually take over the world and what role remains for physicists and, more broadly, humans.
A critical, yet underappreciated fact is that these AI systems rely heavily on vast amounts of training data, most of which are generated and annotated by humans. This dependency raises an intriguing issue: what happens when human-generated data is no longer available, or when AI begins to train on AI-generated data? The phenomenon of AI poisoning, where the quality of AI outputs declines due to self-referencing, demonstrates the limitations of current AI models. For example, in image recognition tasks, such as those involving the MNIST dataset, AI tends to gravitate towards ‘safe’ or average outputs, diminishing originality and accuracy.
In this context, the unique role of humans becomes clear. Physicists, with their capacity for originality, deep understanding of physical phenomena, and the ability to exploit fundamental symmetries in nature, bring invaluable perspectives to the development of AI. By incorporating physics-informed training architectures and embracing the human drive for meaning and discovery, we can guide the future of AI in truly innovative directions. The message is clear: physicists must remain original, pursue their passions, and continue searching for the hidden laws that govern the world and society.
The Madrid Institute of Materials Sciences (CSIC-ICMM) hosted the second training workshop for the SPM 4.0 network. Both Prakhar Dutta and Jiacheng Huang, the two doctoral candidates based at the University of Gothenburg, participated to the event along with the other doctoral candidates of the network.
The second training workshop started with presentations from the doctoral candidates on their progress so far. The training event also consisted of a series of lectures on different topics such as a deep dive into atomic force microscopy and the different modes for the same, basics of deep learning, and an overview of data management plans.
ICMM also hosted some practical sessions where hands-on lectures were given on the use of atomic force microscopy machines and their applications.
DeepTrack 2 Logo. (Image from DeepTrack 2 Project)Artificial Intelligence for Microscopy: From Pixels to Physical Insight
Giovanni Volpe DINAMO 2026
Franschhoek, South Africa
7 April 2026
Optical Fiber Micro/Nano Axicon Tip: An Optical Imaging Platform
Samir K. Mondal
CSIR-CSIO, Chandigarh, India Date: 22 April 2026 Time: 12:30 Place: Online on zoom
Optical fiber tip under structural modifications enhances light-matter interaction by focusing, collecting or modulating light in microscopic scale and combined with waveguide property, it emerges as a potential optical tool, especially for spectroscopic, endoscopic and imaging application. A chemical etching technique has been introduced to permanently modify the tip as Micro/Nano axicon, capable in generating structured beams. The optics of the axicons have been studied in detail and further used in optical imaging experiments, namely phase microscopy, photonic nanojet and nanoscopy. The seminar will highlight first-hand information about the probe and experiments addressing the above-mentioned application.
Short Bio
Dr. Mondal is Chief Scientist at CSIR-CSIO, Chandigarh. He earned his Ph.D. in Electronic Science and M.Sc. in Physics from the University of Calcutta. After postdoctoral research at the University of California, Irvine and the University of Minnesota, he joined Tyndall Research Institute, Ireland.
With over 25 years in optics and photonics, his work spans optical interconnects, photonic crystals, lasers, and fiber instrumentation. He leads research in optical fiber antennas, near-field optics, imaging, and plasmonics, aiming for sustainable photonics platforms.
He collaborates internationally and is known for pioneering micro/nano axicons on fiber tips. He has over 50 publications and serves as an editor and reviewer.
A coarse-grained molecular dynamics framework used to simulate plasmid DNA analyzed via atomic force microscopy (AFM). The resulting images are used to train a U-Net for DNA chain and crossing segmentation and classification. (Image by P. Dutta.)ASAP (AFM Simulation and Analysis Pipeline)
Prakhar Dutta, Jiacheng Huang, Nazli Demirpehlivan, Thomas Catley, Sylvia Whittle, Carlo Manzo, Rahul Nagshi, Rachel Owen, Giovanni Volpe Date: 11th March 2026 Time: 18:00 – 20:00 Place: Aula Medica, Karolinska Institute, Solna
Conference Protein Folding in Real Time, 11-13 March 2026, Stockholm, Sweden
Abstract: Atomic force microscopy (AFM) resolves biological structure and mechanics at high resolution, but produces vast, heterogeneous datasets that are often noisy and very time-consuming to analyse. Although deep learning could automate quality control, segmentation and feature extraction, adoption is limited by scarce ground-truth training data and high technical barriers for experimentalists. Here we present ASAP, an open-source tutorial and pipeline implemented in DeepTrack to provide a reproducible foundation for AI-enabled AFM. At the protein folding conference, a dual-pathway simulation for DNA, offering both molecular dynamics and rapid, non-MD geometries to generate perfect ground truth for segmentation training was presented. By consolidating simulation and learning into a single modular ecosystem, this work enables users to build upon our pipeline to optimize AFM workflows for more efficient data acquisition and robust processing.
Opposing age trajectories and late-life divergence in protein abundance between conditions. (Image by A. Lyu.)Age-Dependent Plasma Protein Dynamics in Health and Disease
Anqi Lyu, Maria Jesus Iglesias, Jochen Schwenk, Mathias Uhlén, Jacob Odeberg, Caroline Adiels, Lynn Butler Date: 11 March 2026 Time: 18:00-20:00 Place: Aula Medica, Karolinska Institute, Solna
Conference Protein Folding in Real Time, 11-13 March 2026, Stockholm, Sweden
Aging is biologically heterogeneous, and chronological age alone cannot explain molecular variability across individuals. Previous studies have shown that disease states can reshape age-associated proteomic trajectories, leading to divergent molecular patterns over time. Here, we explore these dynamics by analyzing age-dependent changes in plasma protein abundance, focusing on differences between case and control conditions during aging. We identify opposing trends and nonlinear transitions, particularly in later life, highlighting critical periods of accelerated molecular change. Beyond descriptive patterns, our analysis emphasizes how disease modifies the underlying structure of aging trajectories, providing insights into the mechanisms of age-related divergence.