Poster presentation by G. Volpe at SPIE-ETAI, San Diego, 24 August 2026

An energy- and data-efficient foundation model for high-content phenotypic screening
Benjamin Midtvedt, Jesús D. Pineda Castro, Henrik Klein Moberg, Jim Denholm, Mattias Goksör, Christos Matsoukas, Bjarki Johannesson, Giovanni Volpe
Date: 24 August 2026
Time: 5:30 PM – 7:30 PM PDT
Place: Conv. Ctr. Exhibit Hall B1

High-content screening (HCS) enables large-scale characterization of cellular responses to chemical and genetic perturbations, yet current deep learning approaches remain limited by label scarcity, batch effects, and high computational cost. We present an energy- and data-efficient foundation model for high-content phenotypic screening that unifies these challenges within a single architecture. Trained on the full JUMP Cell Painting dataset, the model combines active learning with contrastive supervision to focus representation learning on biologically informative variation while reducing sensitivity to technical artifacts. By supporting multimodal integration of molecular metadata alongside fluorescence morphology, the model learns generalizable cellular representations that transfer across experimental conditions and downstream phenotypic tasks.

Presentation by A. Ciarlo at SPIE-OTOM, San Diego, 23 August 2026

Illustration of three different experiments autonomously performed by the SmartTrap system: DNA pulling experiments (top), red blood cell stretching (bottom left), and particle-particle interaction measurements (bottom right). (Image by M. Selin.)
SmartTrap: high-throughput optical tweezers via real-time adaptive control
Antonio Ciarlo, Martin Selin, Giuseppe Pesce, Lars Bengtsson, Joan Camunas-Soler, Vinoth Sundar Rajan, Fredrik Westerlund, L. Marcus Wilhelmsson, Isabel Pastor, Felix Ritort, Steven B. Smith, Carlos Bustamante, Giovanni Volpe
Date: 23 August 2026
Time: 4:55 PM – 5:10 PM PDT
Place: Conv. Ctr. Room 5B

We present SmartTrap, a fully autonomous optical tweezers platform that automates optical trapping experiments. SmartTrap uses deep learning–based 3D particle tracking, adaptive feedback control, and automated microfluidics to perform complete force spectroscopy and manipulation protocols without human intervention. Once initialized, the system operates continuously, autonomously handling trapping, molecular attachment, force application, data acquisition, and bead replacement. We demonstrate its capabilities using automated λ-DNA pulling experiments, which enable high-throughput force-extension and kinetic measurements. These capabilities are implemented using fully open-source control and analysis software with user-friendly interfaces, facilitating adaptation to existing optical tweezers setups and experimental workflows. SmartTrap is a flexible, general-purpose platform for automated optical trapping experiments in biomolecular, colloidal, and cellular systems.

Presentation by A. Lech at SPIE-ETAI, San Diego, 23 August 2026

DeepTrack2 Logo. (Image by J. Pineda)
deeplay: enhancing pytorch with customizable and reusable neural networks
Alex Lech, Mirja Granfors, Jiacheng Huang, Benjamin Midtvedt, Jesús Pineda, Harshith Bachimanchi, Carlo Manzo, Giovanni Volpe
Date: 23 August 2026
Time: 2:15 PM – 2:30 PM PDT
Place: Conv. Ctr. Room 2

Deeplay is a Python-based deep learning library that extends PyTorch, addressing limitations in modularity and reusability commonly encountered in neural network development. Built with a core philosophy of modularity and adaptability. Unlike traditional PyTorch modules, Deeplay allows the properties of submodules to be modified after creation. Layers, blocks, or activation functions can be replaced or reconfigured without rewriting the surrounding architecture, which reduces boilerplate code, improves reuse, and simplifies ablation studies.

Presentation by A. Ciarlo at SPIE-MNM, San Diego, 23 August 2026

Top: single gear; Bottom: the second gear from the right has an optical metamaterial that react to laserlight and makes the gear move. All gears are made in silica directly on a chip. Each gear is about 0.016 mm in diameter. (Image by G. Wang)
Light-driven micromechanical gear systems
Antonio Ciarlo, Gan Wang, Marcel Rey, Mohanmmad Mahdi Shanei, Kunli Xiong, Giuseppe Pesce, Mikael Käll and Giovanni Volpe
Date: 23 August 2026
Time: 9:30 AM – 9:45 AM PDT
Place: Conv. Ctr. Room 11A

We present microscopic geared metamachines driven by optical metasurfaces and fabricated using standard lithography techniques. Metasurface elements convert incident plane-wave illumination into localized optical forces and torques, enabling direct on-chip actuation of micromechanical components without external drives. We demonstrate microscopic gear trains powered by a single optically activated gear and a pinion-and-rack micromachine capable of rotational-to-linear motion conversion and controlled mirror actuation. The platform is compatible with planar fabrication and scalable to parallel integration, providing a compact approach to chip-integrated optical actuation and micromechanical functionality.

Keynote presentation by G. Volpe at SPIE-MNM, San Diego, 23 August 2026

Top: single gear; Bottom: the second gear from the right has an optical metamaterial that react to laserlight and makes the gear move. All gears are made in silica directly on a chip. Each gear is about 0.016 mm in diameter. (Image by G. Wang)
Light-driven metamachines: From metarotors to integrated microscopic gear trains
(Keynote Presentation)
Giovanni Volpe
Date: 23 August 2026
Time: 8:30 AM – 9:05 AM PDT
Place: Conv. Ctr. Room 11A

Microscopic geared metamachines provide a powerful platform to control motion and mechanical work at the microscale. While the miniaturization of mechanical systems has been pursued for decades, integrating drives and gear trains at micrometer scales has remained a major challenge. Recent advances in optical metasurfaces and on-chip fabrication enable light-driven metarotors that transfer torque to passive gears under uniform illumination. These systems have been explored under various conditions by varying light polarization, intensity, and structural symmetry to achieve directional control, tunable rotation rates, and efficient torque transmission. Integrated designs such as rack-and-pinion configurations further demonstrate conversion of rotational motion into linear actuation within compact microsystems. More broadly, geared metamachines extend the landscape of light-powered micro- and nanomachines. In this presentation, I’ll give an overview of this field with a focus on metarotor design, torque transfer across microscopic gear trains, and integrated light-programmable micromechanical systems.

Plenary presentation by G. Volpe at the MüSIM, Münster, Germany, 24 June 2026.

Illustration of three different experiments autonomously performed by the SmartTrap system: DNA pulling experiments (top), red blood cell stretching (bottom left), and particle-particle interaction measurements (bottom right). (Image by M. Selin.)
Smart Machines and Optical Manipulation at the Microscale
Giovanni Volpe
5th Münster Symposium on Intelligent Matter (MüSIM) (Flyer)
Date: 24 June 2026
Time: 15:00
Place: Center for Soft Nanoscience (SoN), Münster, Germany

Microscale systems offer a unique opportunity to engineer machines whose function emerges from the interplay of geometry, interactions, and fluctuations. In this talk, I will present our work on smart machines at the microscale, combining nanofabrication, programmable interactions, and advanced optical methods to design and control colloidal micromechanisms and metamaterials.
I will first introduce how nanotechnology enables the realization of colloidal metamachines and microscopic mechanisms, where shape and mechanical constraints are engineered to produce targeted motion and response in fluid environments. I will then show how smart microscopy and optical manipulation—including high-resolution imaging, automated tracking, and light-based control—allow us to probe these machines in real time and quantify their dynamics. This approach enables precision measurements of effective interaction landscapes, including critical Casimir forces and their relation to fluctuation-induced forces known from QED Casimir physics.

Invited Seminar by G. Volpe at QT community building activity, Stenungsbaden Yacht club, 11 May 2026

(Image created by G. Volpe with the assistance of DALL·E 2)
What remain for physicists to do in the age of AI?
Giovanni Volpe
QT (Quantum Technology Division of MC2, Chalmers University of Technology) community building activity 2026
Date: 11 May 2026
Place: Stenungsbaden Yacht club

In recent years, the rapid growth of artificial intelligence, particularly deep learning, has transformed fields from natural sciences to technology. While deep learning is often viewed as a glorified form of curve fitting, its advancement to multi-layered, deep neural networks has resulted in unprecedented performance improvements, often surprising experts. As AI models grow larger and more complex, many wonder whether AI will eventually take over the world and what role remains for physicists and, more broadly, humans.

A critical, yet underappreciated fact is that these AI systems rely heavily on vast amounts of training data, most of which are generated and annotated by humans. This dependency raises an intriguing issue: what happens when human-generated data is no longer available, or when AI begins to train on AI-generated data? The phenomenon of AI poisoning, where the quality of AI outputs declines due to self-referencing, demonstrates the limitations of current AI models. For example, in image recognition tasks, such as those involving the MNIST dataset, AI tends to gravitate towards ‘safe’ or average outputs, diminishing originality and accuracy.

In this context, the unique role of humans becomes clear. Physicists, with their capacity for originality, deep understanding of physical phenomena, and the ability to exploit fundamental symmetries in nature, bring invaluable perspectives to the development of AI. By incorporating physics-informed training architectures and embracing the human drive for meaning and discovery, we can guide the future of AI in truly innovative directions. The message is clear: physicists must remain original, pursue their passions, and continue searching for the hidden laws that govern the world and society.

MSCA-DN SPM4.0 training event in Madrid, 13-17 April 2026

The Madrid Institute of Materials Sciences (CSIC-ICMM) hosted the second training workshop for the SPM 4.0 network. Both Prakhar Dutta and Jiacheng Huang, the two doctoral candidates based at the University of Gothenburg, participated to the event along with the other doctoral candidates of the network.
The second training workshop started with presentations from the doctoral candidates on their progress so far. The training event also consisted of a series of lectures on different topics such as a deep dive into atomic force microscopy and the different modes for the same, basics of deep learning, and an overview of data management plans.
ICMM also hosted some practical sessions where hands-on lectures were given on the use of atomic force microscopy machines and their applications.

Presentation by S. K. Mondal, online, 22 April, 2026

Optical Fiber Micro/Nano Axicon Tip: An Optical Imaging Platform
Samir K. Mondal
CSIR-CSIO, Chandigarh, India
Date: 22 April 2026
Time: 12:30
Place: Online on zoom

Optical fiber tip under structural modifications enhances light-matter interaction by focusing, collecting or modulating light in microscopic scale and combined with waveguide property, it emerges as a potential optical tool, especially for spectroscopic, endoscopic and imaging application. A chemical etching technique has been introduced to permanently modify the tip as Micro/Nano axicon, capable in generating structured beams. The optics of the axicons have been studied in detail and further used in optical imaging experiments, namely phase microscopy, photonic nanojet and nanoscopy. The seminar will highlight first-hand information about the probe and experiments addressing the above-mentioned application.

Short Bio

Dr. Mondal is Chief Scientist at CSIR-CSIO, Chandigarh. He earned his Ph.D. in Electronic Science and M.Sc. in Physics from the University of Calcutta. After postdoctoral research at the University of California, Irvine and the University of Minnesota, he joined Tyndall Research Institute, Ireland.

With over 25 years in optics and photonics, his work spans optical interconnects, photonic crystals, lasers, and fiber instrumentation. He leads research in optical fiber antennas, near-field optics, imaging, and plasmonics, aiming for sustainable photonics platforms.

He collaborates internationally and is known for pioneering micro/nano axicons on fiber tips. He has over 50 publications and serves as an editor and reviewer.