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Plenary Talk by G. Volpe at OPTIQUE BFC 2026, Dijon, 9 July 2026

Giovanni Volpe gives the plenary Talk “What remains for physicists to do in the age of AI?” at OPTIQUE BFC 2026 in Dijon, France.

What remains for physicists to do in the age of AI?
Giovanni Volpe
OPTIQUE BFC 2026
Date: 9 July 2026
Place: Palais des Congrès, Dijon, France

Giovanni Volpe gave the plenary presentation “What remains for physicists to do in the age of AI?” at OPTIQUE BFC 2026, the biennial congress of the Société Française d’Optique, held in Dijon, France, from 6 to 10 July 2026.

In recent years, the rapid growth of artificial intelligence, particularly deep learning, has transformed fields ranging from the natural sciences to technology. While deep learning can be regarded as a highly sophisticated form of curve fitting, the development of increasingly large and complex neural networks has led to remarkable advances, often surpassing expectations. As AI systems become ever more capable, this raises a fundamental question: what role remains for physicists and, more broadly, for humans?

A critical yet often overlooked aspect of current AI systems is their reliance on vast amounts of training data, much of which ultimately originates from humans. This raises important questions about what happens when human-generated data become scarce or when AI systems increasingly train on AI-generated content. Such feedback can lead models toward increasingly conventional or average outputs, potentially reducing originality and reliability.

In this context, physicists have a distinctive role to play. Their ability to develop fundamental understanding, identify symmetries and physical principles, design experiments, and formulate new questions can provide insights that cannot simply be extracted from existing datasets. Physics-informed approaches can also incorporate this knowledge directly into the architecture and training of AI systems.

The central message is that, in the age of AI, physicists should continue to be original, pursue fundamental questions, and search for the hidden principles governing the physical world.

Invited Talk by G. Volpe at the CECAM workshop “Toward Intelligent Behavior in Macroscopic Active Matter”, Lausanne, 6 July 2026

Top: single gear; Bottom: the second gear from the right has an optical metamaterial that react to laserlight and makes the gear move. All gears are made in silica directly on a chip. Each gear is about 0.016 mm in diameter. (Image by G. Wang).

Autonomous Robots for Intelligent Matter
Giovanni Volpe
Toward Intelligent Behavior in Macroscopic Active Matter
Time: 09:00
Date: 6 July 2026
Place: CECAM-HQ-EPFL, Lausanne, Switzerland

Giovanni Volpe gave the invited talk “Autonomous Robots for Intelligent Matter” at the CECAM workshop “Toward Intelligent Behavior in Macroscopic Active Matter”, held at CECAM-HQ-EPFL in Lausanne, Switzerland, from 6 to 8 July 2026.

Active matter provides a framework for understanding systems composed of self-driven units, ranging from microscopic particles to animal groups and robotic swarms. While traditional active-matter models often describe agents through relatively simple interaction rules, autonomous robotic systems introduce additional capabilities such as sensing, information processing, decision-making, memory, and adaptation.

In his talk, Giovanni discussed how autonomous robots can provide experimental platforms for exploring these emerging forms of intelligent matter. By combining self-propulsion and physical interactions with sensing, feedback, and learning, robotic agents can adapt their behaviour to their surroundings and coordinate with one another, providing a bridge between active-matter physics and embodied intelligence.

These systems offer opportunities to investigate how complex collective behaviours emerge from interactions between individual agents and their environment, while also providing new approaches for designing adaptive and programmable matter. More broadly, they illustrate the growing convergence between statistical physics, robotics, nonlinear dynamics, and machine learning in the study of intelligent active systems.

Plenary presentation by G. Volpe at the MüSIM, Münster, Germany, 24 June 2026.

Illustration of three different experiments autonomously performed by the SmartTrap system: DNA pulling experiments (top), red blood cell stretching (bottom left), and particle-particle interaction measurements (bottom right). (Image by M. Selin.)
Smart Machines and Optical Manipulation at the Microscale
Giovanni Volpe
5th Münster Symposium on Intelligent Matter (MüSIM) (Flyer)
Date: 24 June 2026
Time: 15:00
Place: Center for Soft Nanoscience (SoN), Münster, Germany

Microscale systems offer a unique opportunity to engineer machines whose function emerges from the interplay of geometry, interactions, and fluctuations. In this talk, I will present our work on smart machines at the microscale, combining nanofabrication, programmable interactions, and advanced optical methods to design and control colloidal micromechanisms and metamaterials.
I will first introduce how nanotechnology enables the realization of colloidal metamachines and microscopic mechanisms, where shape and mechanical constraints are engineered to produce targeted motion and response in fluid environments. I will then show how smart microscopy and optical manipulation—including high-resolution imaging, automated tracking, and light-based control—allow us to probe these machines in real time and quantify their dynamics. This approach enables precision measurements of effective interaction landscapes, including critical Casimir forces and their relation to fluctuation-induced forces known from QED Casimir physics.

David Urban receives the Young Research Award at Müsim 2026. Congrats!

David Urban receives the Young Research Award at Müsim 2026. (© CRC 1459 Uni Münster)
David Urban, research scientist at MiNaLab, SINTEF Digital (https://www.sintef.no/en/all-employees/employee/david.urban/), received the Young Research Award at Müsim 2026 [see link: https://www.uni-muenster.de/SFB1459/events/musim/m_sim26/index.html]. Congratulations!

The award recognizes the outstanding paper “Directional flows using capillary assembly of photo-deformable colloidal particles at water-air interfaces“, published in Nature Communications 17, 1004, 2026, which reports on a fundamentally new way of displacing particles along liquid interfaces and tailoring flow patterns using polarized light, photo-deformation and capillary forces.

The award-winning research was carried out during David’s research stay at the Soft Matter Lab, University of Gothenburg, highlighting the value of international collaboration in advancing frontier research.

SmartTrap: automated precision experiments with optical tweezers published in Nature Methods

Illustration of three different experiments autonomously performed by the SmartTrap system: DNA pulling experiments (top), red blood cell stretching (bottom left), and particle-particle interaction measurements (bottom right). (Image by M. Selin.)
SmartTrap: automated precision experiments with optical tweezers
Martin Selin, Antonio Ciarlo, Giuseppe Pesce, Lars Bengtsson, Joan Camunas-Soler, Vinoth Sundar Rajan, Fredrik Westerlund, L. Marcus Wilhelmsson, Isabel Pastor, Felix Ritort, Steven B. Smith, Carlos Bustamante, Giovanni Volpe
Nature Methods (2026)
arXiv: 2505.05290
doi: 10.1038/s41592-026-03129-3

Optical tweezers are widely used in single-molecule biophysics, cell biomechanics and soft matter physics, but require a human operator, limiting throughput and repeatability. Here we present a smart optical tweezers platform, named SmartTrap, capable of performing complex experiments autonomously by integrating real-time three-dimensional particle tracking, custom electronics and a microfluidics system. Through a series of experiments, we demonstrate it can operate continuously, acquiring high-precision data over extended periods of time. By bridging the gap between manual experimentation and autonomous operation, SmartTrap establishes a robust and open-source framework for the next generation of optical tweezers research, capable of performing large-scale studies in single-molecule biophysics, cell mechanics and colloidal science with minimal experimental overhead and operator bias.

Pablo Emiliano Gomez Ruiz defended his PhD thesis on June 15, 2026. Congrats!

PhD defense of Emiliano Gomez-Ruiz. (Photo by H. Zhao.)
Pablo Emiliano Gomez Ruiz defended his PhD thesis on June 15, 2026. Congrats!
The defense took place in PJ Salen lecture hall, Institutionen för fysik, Johanneberg Campus, Göteborg, at 14:00.

Title: Development and application of software to analyze networks with multilayer graph theory and deep learning.

Abstract:
Understanding how the brain is wired is essential, it gives us a new level of insight of its functionality. By modeling the brain as a complex intercon- nected network, the connectome, researchers can abstract biological com- plexity into a mathematical framework suitable for analysis. The connec- tome can be understood by it’s structural links such as neuron’s synapses or by the functional links such as a statistical relationships between neu- ral activity between the brain’s regions. The mapping of these networks is achieved with neuroimaging, while their analysis is driven by the integration of graph theory and deep learning architectures.

In this work, we present a software “Brain Analysis using Graph Theory 2” (BRAPH 2.0), which is a direct solution of the need for a toolbox de- signed for both complex graph theory and deep learning analyses. Central to the software’s architecture is the “Genesis” pseudo-language, which allows researchers to bridge human-readable properties with computer code, facilitating the modular expansion of multilayer graph theory and deep learning pipelines of the software.

The capabilities of this framework are demonstrated through large-scale clinical applications. We analyze sex-related differences in the aging brain using a cohort of 37,543 participants from the UK Biobank. Our results reveal that multilayer metrics, which capture the dynamic interplay between positive and negative functional connections, are significantly more sensitive to sex-related topological changes than traditional unilayer measures.

Furthermore, we implement a Reservoir Computing (RC) pipeline to define computational “Memory Capacity” (MC) as a physical indicator of biological aging. Using the Cam-CAN and LEMON cohorts, we demonstrate that MC reliably predicts age-related decline, particularly within the frontal and parietal regions, and reflects the underlying integrity of white matter tracts and the locus coeruleus.

Thesis: https://hdl.handle.net/2077/91352

Supervisor: Giovanni Volpe
Examiner: Raimund Feifel
Opponent: Maria Guix Noguera
Committee: Remigio Cabrera-Trujillo, Paolo Vinai, Vitali Zhaunerchyk
Alternate board member: Witlef Wieczorek

 

PhD defense of Emiliano Gomez-Ruiz; introduction by the opponent Maria Guix. (Photo by S. Manikandan.)

Matilda Hellström defended her Master thesis on June 15, 2026. Congrats!

Matilda presenting her thesis. (Photo by M. Granfors.)
Matilda Hellström, master student in the program of Complex Adaptive Systems at Chalmers University of Technology, defended her Master thesis on June 15 2026. Congrats!

Title: Prototype Based Segmentation of Bone Tissue Microscopy Images Using Self-Supervised Vision Transformers and Feature Space Similarity

Abstract:
Segmentation of microscopy images constitutes a fundamental task in biomedical research and clinical analysis. However, many segmentation methods rely on large annotated datasets. As the creation of labeled datasets tend to be highly time consuming and difficult to scale, there exists a need for finding alternative segmentation methods that can use unlabeled data directly.

This thesis investigates whether pretrained self-supervised Vision Transformers can be used for prototype based segmentation of bone tissue microscopy images. A segmentation framework based on pretrained DINOv2 backbones was developed, in which positive and negative reference points are used to construct prototype embeddings that guide similarity based segmentation in the learned feature space. The framework was evaluated using multiple DINOv2 backbone variants, feature space analysis and prototype transfer experiments.

The results demonstrated the potential of using pretrained self-supervised Vision Transformers for microscopy image segmentation by showing that the models produce feature representations in which tissue and background regions become partially separable. Despite being trained on natural RGB images rather than microscopy data, the pretrained backbones enabled segmentation of bone structures using the proposed similarity based segmentation framework.

Supervisor: Mirja Granfors Pineda
Examiner: Giovanni Volpe
Opponent: Patrik Dennis

Place: FL71
Time: 15 June, 2026, 09:00

Protein Dynamics Beyond Structure Prediction on ArXiv

Computational advances in protein folding studies. Current approaches address multiple levels of resolution and methodological frameworks, however, none of the existing methods provides quantitative and dynamic information of the relationship between protein sequence and folding mechanism at all-atom resolution and at scale. (Graphics by J. Sacquegno.)
Protein Dynamics Beyond Structure Prediction
Juliette Griffié, Sviatlana Shashkova, Antonio Ciarlo, Sreekanth K. Manikandan, Claes Andréasson, Malin Bäckström, Tristan Bereau, Hjalmar Brismar, Carlos Bustamante, Marta Carroni, Roberto Covino, Andreas Dahlin, Sebastian Deindl, Lucie Delemotte, Arne Elofsson, John Eriksson, Giovanna Fragneto, Anders Gunnarsson, Per Hammarström, Caroline Ingre, Christian Kaiser, Petronella Kettunen, Mark C. Leake, Benjamin Loos, Anna Månberg, Antonia S. J. S. Mey, Richard Neutze, Thomas Nyström, Karl Palmås, Charley Schaefer, Markus J. Tamás, Nicola Ticozzi, Tomás S. Pilvelic, Jacopo Sacquegno, B.M. (Betty)Tijms, Gunnar von Heijne, Björn Wallner, Vitali Zhaunerchyk, Simon Olsson, Joana B. Pereira, Julia Fernandez-Rodriguez, Fredrik Westerlund, Giovanni Volpe
arXiv: 2606.08647

How microorganisms respond to and interact with their environment can vary significantly from individual to individual, which can have important microbiological and ecological implications. However, most microscopy techniques can only observe motile microorganisms for short times because of their limited fields of view. Using Lagrangian tracking, a single microorganism can be followed in 3D, potentially indefinitely, allowing to decipher individual phenotypical traits. Current Lagrangian tracking methods use the fluorescence signal emitted by the microorganism as feedback to keep it in focus. However, over long times, epifluorescent imaging can induce photobleaching and photodamage, and importantly, not all microorganisms can easily be made fluorescent. Additionally, traditional algorithms used in feedback loops to determine microorganism position are prone to errors, especially in optically complex media. Here, we present a faster, more reliable, and versatile Lagrangian tracking method that uses deep learning to determine the 3D position of the microorganism. This new method demonstrates enhanced accuracy and speed in tracking fluorescent bacteria with fluorescence microscopy also in optically complex media. Furthermore, we track bacteria with other microscopy modalities, such as brightfield microscopy — for example, this enables us to track magnetotactic bacteria, which cannot be made fluorescent without degrading their magnetotactic properties. These novel capabilities allow to extract previously inaccessible quantitative information, significantly advancing the study of microorganism behavior — and thus opening new avenues for research in complex biological and ecological systems.

Beyond the black box: towards an open and citable software ecosystem in photonics published in Journal of Physics: Photonics

A centralized, peer-reviewed ecosystem in J. Phys. Photonics where human agents and/or AI agents co-develop validated, documented software. (Image from the manuscript.)
Beyond the black box: towards an open and citable software ecosystem in photonics
Anoop C Patil, Maciej Trusiak, Fei Xia, Liangcai Cao, Carlo Manzo and Giovanni Volpe
Journal of Physics: Photonics 8, 020201 (2026)
doi: 10.1088/2515-7647/ae68cd

This editorial draws attention to a major issue in photonics: important research software is often hidden, undocumented, and lost over time, making results hard to reproduce. The rise of AI-generated code increases this problem by adding more ‘black box’ systems. To address this, J. Phys. Photonics is introducing Software Articles, a new article type allowing researchers to publish, validate, and share their code as formal scientific outputs. This initiative aims to promote transparency, reproducibility, and proper credit for developers. Open and peer-reviewed software helps the community verify results, reduce duplication of effort, and build lasting tools, ensuring that computational methods become reliable, accessible, and integral to scientific progress.

Invited Seminar by G. Volpe at QT community building activity, Stenungsbaden Yacht club, 11 May 2026

(Image created by G. Volpe with the assistance of DALL·E 2)
What remain for physicists to do in the age of AI?
Giovanni Volpe
QT (Quantum Technology Division of MC2, Chalmers University of Technology) community building activity 2026
Date: 11 May 2026
Place: Stenungsbaden Yacht club

In recent years, the rapid growth of artificial intelligence, particularly deep learning, has transformed fields from natural sciences to technology. While deep learning is often viewed as a glorified form of curve fitting, its advancement to multi-layered, deep neural networks has resulted in unprecedented performance improvements, often surprising experts. As AI models grow larger and more complex, many wonder whether AI will eventually take over the world and what role remains for physicists and, more broadly, humans.

A critical, yet underappreciated fact is that these AI systems rely heavily on vast amounts of training data, most of which are generated and annotated by humans. This dependency raises an intriguing issue: what happens when human-generated data is no longer available, or when AI begins to train on AI-generated data? The phenomenon of AI poisoning, where the quality of AI outputs declines due to self-referencing, demonstrates the limitations of current AI models. For example, in image recognition tasks, such as those involving the MNIST dataset, AI tends to gravitate towards ‘safe’ or average outputs, diminishing originality and accuracy.

In this context, the unique role of humans becomes clear. Physicists, with their capacity for originality, deep understanding of physical phenomena, and the ability to exploit fundamental symmetries in nature, bring invaluable perspectives to the development of AI. By incorporating physics-informed training architectures and embracing the human drive for meaning and discovery, we can guide the future of AI in truly innovative directions. The message is clear: physicists must remain original, pursue their passions, and continue searching for the hidden laws that govern the world and society.