Tag: Sara Garcia-Ptacek

Mapping individual molecular connectomes in Alzheimer’s disease published in Alzheimer’s & Dementia

Diagnostic classification. (Image from the article.)
Mapping individual molecular connectomes in Alzheimer’s disease
Zhilei Xu, Mite Mijalkov, Jiawei Sun, Yu-Wei Chang, Arianna Sala, Giovanni Volpe, Mario Severino, Mattia Veronese, Sara Garcia-Ptacek, Joana B. Pereira, for the Alzheimer’s Disease Neuroimaging Initiative
Alzheimer’s & Dementia 22, e71310 (2026)
DOI: 10.1002/alz.71310

INTRODUCTION
Mapping individual differences is crucial to improve personalized medicine approaches in Alzheimer’s disease (AD), which is characterized by strong inter-individual variability in the accumulation patterns of tau and amyloid beta pathology.

METHODS
We assess the progression of AD across the disease continuum by building individual molecular connectomes using longitudinal positron emission tomography (PET) data.

RESULTS
We demonstrate that these connectomes constitute a unique fingerprint, capable of identifying a single individual from a large group of subjects. Alterations in the connectomes discriminate different diagnostic groups and predict cognitive decline to a higher extent than conventional PET measures. We introduce a novel gene-specific transcription network analysis that linked individual tau and amyloid connectomes to a common transcriptomic profile of apoptosis, with the tau connectome being specifically related to pyrimidine metabolism, and the amyloid connectome to histone acetylation.

DISCUSSION
Individual molecular connectome mapping provides a novel and sensitive framework to monitor AD progression.

Highlights

  • Individual molecular connectomes constitute a unique fingerprint, capable of identifying a single individual from a large group of subjects.
  • Alterations in individual molecular connectomes significantly increase both across the Alzheimer’s disease (AD) continuum and over time.
  • Alterations in individual molecular connectomes discriminate different diagnostic groups and predict cognitive decline to a higher extent than conventional positron emission tomography measures.
  • Susceptibilities of individual tau and amyloid connectomes to AD are linked to a common transcriptomic profile of apoptosis, with the tau connectome being specifically related to pyrimidine metabolism, and the amyloid connectome to histone acetylation.

Computational memory capacity predicts aging and cognitive decline published in Nature Communications

Memory capacity in aging. A Brain reservoir computing architecture with uniform random signals applied to all nodes. (Image from the article.)
Computational memory capacity predicts aging and cognitive decline
Mite Mijalkov, Ludvig Storm, Blanca Zufiria-Gerbolés, Dániel Veréb, Zhilei Xu, Anna Canal-Garcia, Jiawei Sun, Yu-Wei Chang, Hang Zhao, Emiliano Gómez-Ruiz, Massimiliano Passaretti, Sara Garcia-Ptacek, Miia Kivipelto, Per Svenningsson, Henrik Zetterberg, Heidi Jacobs, Kathy Lüdge, Daniel Brunner, Bernhard Mehlig, Giovanni Volpe, Joana B. Pereira
Nature Communications 16, 2748 (2025)
doi: 10.1038/s41467-025-57995-0

Memory is a crucial cognitive function that deteriorates with age. However, this ability is normally assessed using cognitive tests instead of the architecture of brain networks. Here, we use reservoir computing, a recurrent neural network computing paradigm, to assess the linear memory capacities of neural-network reservoirs extracted from brain anatomical connectivity data in a lifespan cohort of 636 individuals. The computational memory capacity emerges as a robust marker of aging, being associated with resting-state functional activity, white matter integrity, locus coeruleus signal intensity, and cognitive performance. We replicate our findings in an independent cohort of 154 young and 72 old individuals. By linking the computational memory capacity of the brain network with cognition, brain function and integrity, our findings open new pathways to employ reservoir computing to investigate aging and age-related disorders.