Poster Presentation by F. Skärberg at SPIE-ETAI, San Diego, 22 August 2022

411nm Silica particles inside living cells. (Image by F. Skärberg.)
Holographic characterisation of biological nanoparticles using deep learning
Fredrik Skärberg, Erik Olsén, Benjamin Midtvedt, Emelie V. Wesén, Elin K. Esbjörner, Giovanni Volpe, Fredrik Höök, Daniel Midtvedt
Submitted to SPIE-ETAI
Date: 22 August 2022
Time: 17:30 (PDT)

Optical characterization of nanoparticles in/outside cells is a challenging task, as the scattering from the nanoparticles is distorted by the scattering from the cells. In this work, we demonstrate a framework for optical mass quantification of intra- and extracellular nanoparticles by leveraging a novel deep learning method, LodeSTAR, in combination with off-axis twilight holography. The result provides new means for the exploration of nanoparticle/cell interactions.

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