Author: Anqi Lyu

Poster by Anqi Lyu at the Protein Folding in Real Time conference, Stockholm, 11 March 2026

Opposing age trajectories and late-life divergence in protein abundance between conditions. (Image by A. Lyu.)
Age-Dependent Plasma Protein Dynamics in Health and Disease
Anqi Lyu, Maria Jesus Iglesias, Jochen Schwenk, Mathias Uhlén, Jacob Odeberg, Caroline Adiels, Lynn Butler
Date: 11 March 2026
Time: 18:00-20:00
Place: Aula Medica, Karolinska Institute, Solna
Conference Protein Folding in Real Time, 11-13 March 2026, Stockholm, Sweden

Aging is biologically heterogeneous, and chronological age alone cannot explain molecular variability across individuals. Previous studies have shown that disease states can reshape age-associated proteomic trajectories, leading to divergent molecular patterns over time. Here, we explore these dynamics by analyzing age-dependent changes in plasma protein abundance, focusing on differences between case and control conditions during aging. We identify opposing trends and nonlinear transitions, particularly in later life, highlighting critical periods of accelerated molecular change. Beyond descriptive patterns, our analysis emphasizes how disease modifies the underlying structure of aging trajectories, providing insights into the mechanisms of age-related divergence.

Anqi Lyu joins the Soft Matter Lab

Anqi Lyu starts her PhD at the Physics Department of the University of Gothenburg on 8 January 2025.

Anqi has a Master degree in Medical Bioinformatics from University of Verona, Italy.

In her PhD, she will focus on delineating how plasma factors globally influence endothelial cells, with emphasis on their roles in health, ageing and disease, by utilizing computational tools in combination with interdisciplinary approaches.