Anqi Lyu, Maria Jesus Iglesias, Jochen Schwenk, Mathias Uhlén, Jacob Odeberg, Caroline Adiels, Lynn Butler
Date: 11 March 2026
Time: 18:00-20:00
Place: Aula Medica, Karolinska Institute, Solna
Conference Protein Folding in Real Time, 11-13 March 2026, Stockholm, Sweden
Aging is biologically heterogeneous, and chronological age alone cannot explain molecular variability across individuals. Previous studies have shown that disease states can reshape age-associated proteomic trajectories, leading to divergent molecular patterns over time. Here, we explore these dynamics by analyzing age-dependent changes in plasma protein abundance, focusing on differences between case and control conditions during aging. We identify opposing trends and nonlinear transitions, particularly in later life, highlighting critical periods of accelerated molecular change. Beyond descriptive patterns, our analysis emphasizes how disease modifies the underlying structure of aging trajectories, providing insights into the mechanisms of age-related divergence.